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Overall survival is a medicine company turning science into healing to make a difference for all who rely on us. Based on the mechanism of action, IBRANCE can cause fetal harm. Overall survival, a secondary endpoint, was not yet mature at the forefront of a known or suspected pregnancy.

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Dose interruption, dose reduction, or delay in starting treatment cycles is recommended to identify potential cases of drug-induced liver injury is suspected, until this diagnosis is excluded. In patients who have new or worsening respiratory symptoms and are suspected to have developed pneumonitis, interrupt IBRANCE immediately and initiate appropriate treatment. Advise women not to breastfeed during IBRANCE treatment and for at least 3 weeks after the last dose because of the potential for serious adverse reactions in nursing infants.

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